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Upon inhalation, a muco-trapping variant of motavizumab an antibody targeting respiratory syncytial virus with improved binding decreased the fraction of fast-moving respiratory syncytial virus in mice, rat and lamb models, in an Fc-glycan-dependent manner, by ~2030-fold 77

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To a solution of methyl 3-(1-(4-methoxybenzyl)-1H-pyrazol-3-yl)-2-oxopropanoate (9.8 g, 34.0 mmol) in THF (100 mL) was added NaBH 4 (1.929 g, 51.0 mmol) at 0 C