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Tao, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Plasmids construction Clasp2-WT encoding mouse WT Clasp2 was subcloned into EcoRI and SalI sites of the pEGFP-C1 vector to construct the pEGFP-C1-Clasp2-WT plasmid, which was further used as a template to construct pEGFP-C1-Clasp2-S1025A and pEGFP-C1-Clasp2-S1025D by site-directed mutagenesis