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Some research suggests that antidepressants work better when a patient also receives added Vitamin B12

Long-chain fatty acids cannot cross the mitochondrial membrane on their own

Vano-Galvan S, Hermosa-Gelbard A, Sanchez-Neila N, Miguel-Gomez L, Saceda-Corralo D, Rodrigues-Barata R, Ma DL, Jaen P (2016) Pulse corticosteroid therapy with oral dexamethasone for the treatment of adult alopecia totalis and universalis

Although there is currently no evidence to suggest any adverse side effects from excess vitamin B12 supplementation, there is no need to take excessively high amounts of the vitamin, as the body can only absorb so much anyway

If infusing it in a water or saline diluent it remains mainly GSH and then can enter the plasma where it has the best chance of having a higher GSH to GSSG ratio until delivery to target tissue