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There is no indication that DSIP produces the kind of dependency that opiate medications do despite the fact that both work on the same receptors in the central nervous system

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[114] demonstrated significant pain reduction with lidocaine in female patients following laparoscopic gynecological surgery, with no notable adverse effects

The majority of individuals do not encounter any adverse effects from using NAD+

Human clinical trials are sparse, with no large-scale randomized controlled trials demonstrating efficacy or optimal dosing in population-level settings

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