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It is naturally synthesized within the cytosol of almost every cell in the body, with the highest concentrations found in the liver, lungs, and brain

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As GPX4 activity is heavily dependent on GSH availability, upregulation of SLC7A11 enhances GPX4 function and prevents ferroptosis

Lim U, Lampe J TMAO, the gut microbiome, and colorectal cancer risk in the multiethnic cohort Liu X, Liu H, Yuan C, Zhang Y, Wang W, Hu S, Liu L, Wang Y (2017) Preoperative serum TMAO level is a new prognostic marker for colorectal cancer