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A study conducted in India has demonstrated that curcumin could significantly elevate the blood concentration of Bedaquiline by limiting P-glycoprotein-mediated efflux to improve the absorption and slow the metabolism of Bedaquiline, so it is advised not to combine curcumin with Bedaquiline to prevent potential adverse reactions (Kotwal et al., 2020)

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Larger nanoparticles (diameter, 50200 nm) tend to cross intestinal epithelial cells by endocytosis

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