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doi: 10.1186/s13046-019-1206-z 275 Toral-RiosDPatio-LpezGGmez-LiraGGutirrezRBecerril-PrezFRosales-CrdovaAet al

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Naast zijn antioxiderende werking heeft glutathion nog twee andere belangrijke functies: het is belangrijk voor de ontgifting van het lichaam zelf en verbetert de werking van het immuunsysteem

2.2.2 Amino acid metabolism Mounting studies indicate that cystine uptake via System Xc is crucial for maintaining glutathione (GSH) levels and inhibiting ferroptosis ( (a special cystine/glutamate transporter) exchanges intracellular glutamate for extracellular cystine in a 1:1 ratio ( transport may be inhibited by elevated extracellular glutamate levels

576,577 Activation of the EMT program enables tumor cells to resist the therapeutic agents, which is consistent with the attribute of CSCs