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When You Might Actually Consider Refrigeration While we generally advise against it, there are specific scenarios where the fridge might cross your mind

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Getting the dose right can mean the difference between a calm, comfortable pet and no noticeable effects at all

Instead, raised levels may indicate: Liver disease (impaired B12 storage and release) Myeloproliferative disorders or certain leukaemias Renal impairment Recent B12 supplementation or injection Isolated high B12 is usually due to supplementation or binding-protein changes and should be assessed against clinical context and other tests

A recent investigation supports this assertion, revealing that a combination of genetic and acquired/environmental factors contribute to the ethnic differences in serum vitamin B12 levels [39]

Unmixed powder keeps best frozen or refrigerated and out of light