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19 BittencourtL

R.DewitzC.De ZenF.et al (2014a)

Furthermore, deficiency or mutation of nuclear factor erythroid 2-related factor 2 (Nrf2) has been demonstrated to exacerbate mitochondrial dysfunction and metabolic dysregulation induced by ROS ( Conversely, damaged mitochondria further aggravate OS

These findings are summarized in Table 1 and illustrated in Figure 1

To detect the actin cytoskeleton, neurons were stained with a solution of 1 g/mL Alexa-Fluor 647-phalloidin (Thermo Fisher) in PBS for 60 minutes and rinsed with PBS, 3 times, 5 minutes each