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Additionally, continued exposure of T cells at sites of inflammation elicits high levels of reactive oxygen species (ROS), which results decreased intracellular levels of GSH, dysregulation of redox balance, impaired signal transduction of the TCR/CD3 complex, and ultimately to synovial T cell hyporesponsiveness during RA [137]

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164 10 Dietary and Lifestyle Considerations Diet and Weight Loss Obesity has been described as the most important risk factor for obstructive sleep apnea, and weight loss is recommended for most patients with obstructive sleep apnea and excess weight

Cell Host Microbe 8:6876 Serafini A, Tan L, Horswell S, Howell S, Greenwood DJ, Hunt DM, Phan MD, Schembri M, Monteleone M, Montague CR et al (2019) Mycobacterium tuberculosis requires glyoxylate shunt and reverse methylcitrate cycle for lactate and pyruvate metabolism