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IGF-1 LR3 ZPHC 0,2 (1 ) :

doi: 10.1016/j.cmet.2011.02.018 71 DruartC.AlligierM.SalazarN.NeyrinckA

Mitophagy and Mitochondrial Functions Engagement in mitochondrial homeostasis is observed to be the coherent point in the in vivo model studies based on different types of animals and humans

Oxidative stress in RA overloads the UPS, leading to the accumulation of ubiquitin conjugates and exacerbating cellular damage and inflammation

Increased oxidative stress causes modifications of all subcellular organelles, including oxidation of endoplasmic reticulum Ca 2+ -ATPase and contractile proteins (actin and myosin being the most important) resulting in contractile dysfunction (Steinberg 2013)