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Cloudiness or precipitation in a clear serum may indicate peptide aggregation from pH shift or temperature damage

That being said, many clinical trials involve dozens of sites which could generate a steady flow of needed updates

78 SakuraiT.KanayamaM.ShibataT.ItohK.KobayashiA.YamamotoM.et al (2006)

Nat Rev Dis Primers 4 , 21 (2018)

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Clinical studies have confirmed that the number of Ki67 + and phosphorylated STAT3 + hepatocytes and cholangiocytes in patients with alcoholic cirrhosis is significantly decreased, indicating that hepatocyte proliferation is inhibited (Horiguchi et al., 2007)