liver glutathione system Complex with Milk Thistl Extract | & Immune Glutathione: Pharmacological aspects and implications

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[DOI] [PubMed] [Google Scholar] 97

2019 Nov 27;14:9217-9234

Toklu HZ, Tunali-Akbay T, Erkanli G, Yksel M, Ercan F, Sener G

In the treatment of breast cancer, anti-estrogen tamoxifen, the drug most often used for the long-term treatment of early breast cancer, can induce apoptosis in many cells, and this effect may be mediated by ROS generation in the mitochondria of breast cancer cells [71]

In view of the above, the notion that SIRT1 might preserve the integrity of mitochondrial function under oxidative stress brought on by chemotherapy is supported by the capacity of SP or L-Car to improve mitochondrial stress-induced disturbed steroidogenesis markedly