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Animals 9, 566

CRH signaling axis: Mechanistic evidence from stress-asthma animal models demonstrate that endogenous opioid signaling stimulates the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic and adrenomedullary (SAM) system (120123)

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Thus, while the prodrug approach holds substantial promise for broadening PROTAC therapeutic applicability, overcoming its inherent dependence on heterogeneous microenvironmental conditions, delivery uncertainties, and synthetic complexities remains critical for advancing these technologies toward widespread clinical use

The upper clear aqueous layer was transferred to a new tube and 1 volume of 70% ethanol was added and mixed by vortexing

Czerwinski, M., Gibbs, J