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In recent years, candidate genes studies from peripheral blood have reported changes in DNAm associated with heavy CU in genes involved in dopamine transmission, such as DRD 2 (Gerra et al., Reference Gerra, Jayanthi, Manfredini, Walther, Schroeder, Phillips and Donnini2018), DAT1 (Grzywacz et al., Reference Grzywacz, Barczak, Chmielowiec, Chmielowiec, Suchanecka, Trybek and Rubis2020) and COMT (Van der Knaap et al., Reference Van der Knaap, Schaefer, Franken, Verhulst, van Oort and Riese2014) and in the CB1 and CB2 receptors genes part of the endocannabinoid system (Rotter et al., Reference Rotter, Bayerlein, Hansbauer, Weiland, Sperling, Kornhuber and Biermann2012