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The storage conditions matter because the proapoptotic domain can degrade if exposed to moisture or temperature fluctuations

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Capone S, Brown A, Hartnell F, Sorbo MD, Traboni C, Vassilev V, et al

These are described as community-reported tolerability observations, not a controlled finding but they're consistent with how topical actives behave generally

In general, we advise a weekly shot for four weeks, then a maintenance dose per month

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