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32 In contrast to GHD or populations defined by a medical disease, the ISS population is heterogeneous, including patients with familial short stature, CGD, partial or transient GH deficiency or resistance, and intrinsic short stature due to unidentified condition

Human evidence is limited to three small pilot studies (fewer than 30 total subjects) covering interstitial cystitis, knee pain, and IV safety, none with placebo controls

Availability of cystine/cysteine is the rate-limiting step in GSH synthesis counteracting ROS 18 , which prevents the execution of ferroptosis, an oxidative, non-apoptotic and iron-dependent form of regulated cell death caused by ROS-mediated lipid peroxidation 13,19,20

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doi: 10.3390/v15051183 160 LiJAndikaIBShenJLvYJiYSunLet al

doi: 10.1016/j.lfs.2021.119961 235 El-DesoukyMAFahmiAAAbdelkaderIYNasraldinKM