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PLoS One 14 (6), e0218533

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These data further support a model that the catabolite intermediate IP drives SKN-1 activation

These effects appear to be more pronounced in aged than in younger subjects (n = 21, age 4875) (Mahdi et al., 2019), and does not depend on efficacy of blood glucose-lowering therapy in T2D patients (n = 16, average age 64) (Mahdi et al., 2018)

The total GSH level vs storage time in months from those cohorts are shown in Figure 1, a best fit line and slope were reported for each CON, BP and SZ group

Collectively, these results indicate that oxidative stress is a powerful driving force behind antiretroviral-induced toxicity and has important roles in premature-and-accelerated-aging symptoms (Blas-Garcia et al., 2011)