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-MSH is produced in the pituitary gland and is involved in various physiological processes, including skin tanning, energy homeostasis, and the suppression of inflammation

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Preclinical studies have identified multiple potential mechanisms of resistance that can develop at various points in the course of ADC trafficking through cancer cellsfrom receptor binding, to internalization and processing of the ADC, to efflux of the payload out of the cell, as well as antibody-dependent cellular cytotoxicity (ADCC) 1,2,3 (Fig

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