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Since its development, AOD-9604 has been the subject of over 16 peer-reviewed publications spanning three decades, including six randomized, double-blind, placebo-controlled human clinical trials involving more than 900 participants

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However, mandatory fortification coupled with personal consumption of folic acid-containing supplements exposes a significant proportion of such populations to amounts of folic acid well above the recommended upper tolerable intake level established by the Institute of Medicine (77)

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[DOI] [PubMed] [Google Scholar] 15.Pereira-Silva M., Martins A.M., Sousa-Oliveira I., Ribeiro H.M., Veiga F., Marto J., Paiva-Santos A.C