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The researchers also found that the cell deaths were promoted by addition of Fe, while inhibited by antioxidants (ferrostatin and Vitamin E) and iron chelator ciclopirox olamine [277]

This polypharmacological approach stands in contrast to conventional chemotherapeutics, which typically target single molecules and are therefore more susceptible to resistance development (Liao et al., 2023)

The current study has several limitations that need to be addressed in future research

NAD+ IV infusions deliver a higher dose slowly over time and are often chosen for more comprehensive cellular support

It is estimated that approximately half of the biotin and half of the vitamin K in humans comes from their intestinal bacteria [43]

Of note, the patient was found to have a lice infestation of the scalp and was treated with permethrin 5% cream during hospitalization