Mitochondrial-derived peptide MOTS-c increases adipose thermogenic activation to promote cold adaptation
Protein-level mutant p53 reporters identify druggable rare precancerous clones in noncancerous tissues
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As we get wiser, our skin can lose elastin and collagen, our moisture barrier weakens, damaged protein builds up, subcutaneous fat thins, antioxidants dwindle, and stem cells are less willing to rebuild
4.4 Huntington's disease (HD) HD constitutes a genetic neurodegenerative condition distinguished by the aggregation of mutant huntingtin proteins, a progressive decline in striatal and cortical neuronal populations, motor impairments, psychiatric manifestations, and cognitive deterioration (72)
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