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Description

Nature 545, 4853

doi: 10.1021/acs.nanolett.0c04753 206 HirschhornTStockwellBR

The increased abundance of proteins involved in chronic liver inflammation, including (i) antioxidant defense such as glutathione peroxidase 2, biliverdin reductase, and superoxide dismutase 2, (ii) proteins associated with liver fibrosis such as matrix metalloproteinases, as well as (iii) key components of neutrophil degranulation, support the notion that an inflammatory condition of the liver may prevail in UGT2B17-deficient individuals