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The mechanism suggested by Stenuit et al

FIGURE 3 3.4 Evaluation of enzymatic antioxidants and possible sources of ROS in monocytes In the next step, we assessed other essential components of the antioxidant defense system: catalase (CAT), superoxide dismutases (SODs), peroxiredoxin 1 (PRDX1), and heme oxygenase 1 (HMOX1) (Figure 4A)

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Melatonin has an easier access to subcellular organelles such as the mitochondria, the primary sites for ROS production due to their lipophilic and hydrophilic characteristics (Reiter et al., 2003

Allele frequencies for genetic polymorphism are such that ~1 in 300 Caucasians is homozygous for a defective allele or alleles for the trait of very low activity, ~11% of people are heterozygous and have intermediate activity