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Mol Psychiatry (1998) 3:2201.10.1038/sj.mp.4000370 120 BeyerJLKrishnanKR

High-income countries typically exhibit higher incidence rates than low- and middle-income countries, although mortality rates are often lower due to better access to early detection and treatment

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These changes reflect mercurys toxic impact, which disrupts cellular homeostasis, elevates reactive oxygen species (ROS), and weakens antioxidant defenses

likely regulate oxidative stress by influencing ROS-forming enzymes and modulating transcription factors like Nuclear factor erythroid-2-related factor 2 (NRF-2) and NF-B (12)

Xiang J, Lv M, Luo Y, Ke K, Zhang B, Wang M et al (2025) Mechanistic studies of Ca(2+)-induced classical pyroptosis pathway promoting renal adhesion on calcium oxalate kidney stone formation