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Excessive ionophore administration can overwhelm these defenses, leading to systemic copper poisoning, characterized by hepatotoxicity, nephrotoxicity, and hematopoietic suppression [239]

[173] Parajuli RP, Goodrich JM, Chou HN, Gruninger SE, Dolinoy DC, Franzblau A, Basu N

The GI adaptation that happens at each dose tier is what allows you to tolerate higher doses later

The lipids forming the skins lamellar barrier consist of 50% ceramides in the stratum corneum, primarily CER[AH], CER[NS] and CER[AS] [36]

How amounts of B vitamins in supplements compare to the amounts you actually need - the results may surprise you