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doi: 10.1074/jbc.M805711200

The safety and effectiveness of V1a antagonists in ASD have been studied in a few clinical trials [142]

Any breakdown in the homeostatic balance between ROS formation and antioxidant capacity in the seminal plasma of human semen leads to OS when highly reactive ROS overwhelms the antioxidant defense systems (66)

Route of administration to bypass the BBB : Intrathecal administration of drugs enables the delivery of therapeutic products to the cerebrospinal fluid, which can be distributed throughout the ventricular system and eventually enter the brain parenchyma

Another aspect of the present invention is a carrier-linked prodrug comprising a biodegradable hydrogel of the present invention as carrier, wherein a number of permanent linkages of the backbone moieties exist with a transient prodrug linker to which a biologically active moiety is covalently attached