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doi: 10.1136/annrheumdis-2014-207169 43

Cysteine bioavailability: main players and regulators As mentioned above, the bioavailability of cysteine in a cancer cell can influence metabolic fitness and the development of therapy resistance

Severe gastrointestinal distress: Persistent vomiting or diarrhea that leads to dehydration

Inclusion criteria This review considered peer-reviewed studies of L-carnitine supplementation in subjects with coronary artery disease across predefined designs, each with a distinct role, including preclinical evidence such as animal studies which provided mechanistic evidence and insights on emerging pathways, as well as clinical evidence such as case reports, cross-sectional studies, observational studies, retrospective analyses, randomized controlled trials, systematic review and meta-analyses which provided primary evidence as well as quantitative analysis of clinical endpoints

Paranjpe, S