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Find out if supplementing with B-6 or B-12 is beneficial and whether B-6 can interfere with drugs for Parkinson's

It depends, of course

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NNMT is upregulated in white adipose tissue in obesity and in cancer cachexia models, and NNMT enzymatic activity has been implicated in maintaining the adipocyte fat-storage phenotype through SAM-dependent epigenetic remodeling