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The testosterone elevation it produces is generally in the low-to-mid normal range for healthy young men, typically 400 to 600 ng/dL depending on baseline function

Sodium thiosulphate (ST) was infused with SNP at molar ratios of 1:4, 1:5, and 1:10

(2.1) The recommended dose of ALIMTA, administered as a single agent or with cisplatin, in patients with creatinine clearance of 45 mL/minute or greater is 500 mg/m2 as an intravenous infusion over 10 minutes on Day 1 of each 21-day cycle

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The result is a cortisol curve that is flat, low and unresponsive rather than high and reactive