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Given the link between chronic inflammation and functional decline during aging 2 , we assessed systemic physiological outcomes

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To determine whether the ASXLs binding mechanism is conserved in BRD4 ET , we tested ASXL2 EBM (aa 615-628 of ASXL2) and ASXL3 EBM (aa 10081021 of ASXL3) peptides in 1 H, 15 N HSQC titration experiments and fluorescence spectroscopy (Fig

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It does so through an epigenetic mechanism, where FGF15/19 interacts with its target nuclear receptors, such as small heterodimer partner (SHP), which then recruits DNA methyltransferase-3a (DNMT3a) to the lipogenic gene loci, including FASN