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Renal mTORC1 activation is associated with disease activity and prognosis in lupus nephritis

Just think about fluid pressure in a small container being pushed, pushed, pushed until the can or the container is ready to explode, and how multiple features, multiple variables could impinge on that and create that pressure

ALA primarily acts as a multifunctional redox modulator and mitochondrial cofactor, UA promotes mitochondrial quality control through mitophagy and mitochondrial biogenesis, and EGT functions as a stable cytoprotective antioxidant with selective cellular uptake

ROS generated by the Fenton reaction tends to react with phospholipids (PL) to form hydroperoxy-phospholipids (PLOOH), which are the main elimination target of GPX4 (Wiktorowska-Owczarek et al., 2015)

[DOI] [PMC free article] [PubMed] [Google Scholar] 152.Joshi S, Singh AR, Durden DL

doi: 10.3390/bioengineering6040113 20 CleversH