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C4a also induces the generation of reactive oxygen species (ROS) via NADPH oxidase, contributing to oxidative stress, mitochondrial dysfunction, and downstream redox-sensitive signaling cascades such as NF-B and AP-1

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In another study, the 5-methyl-THF content in blanched vegetables decreased with the time of frozen storage at 18 C by 98% in cauliflower, 24% in broccoli, 39% in peas and spinach just after 3 months, and by 8298% in all of them after 6 months