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Exp Neurol 215(1):178190 Chen ZY, Ieraci A, Teng H, Dall H, Meng CX, Herrera DG, Nykjaer A, Hempstead BL, et al

Both candidates are designed to move beyond single-pathway GLP-1 therapy, but they take very different routes: CagriSema combines an amylin analog with semaglutide, while Retatrutide compresses GIP, GLP-1, and glucagon agonism into one investigational peptide

2 Rakhmanov Department of Dermatology and Venereal Diseases, I.M.Sechenov First Moscow State Medical University of the Russian Federation, Moscow 119435, Russia