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While the catalytic core does possess a weak affinity for PIP 2 , the C2 domain has been shown to mediate calcium-dependent phospholipid binding as well

It was shown, in vitro, in isolated-perfused rat liver models, that adding human apoC1 to chylomicrons [54] or triglycerides (TG) emulsions [55] led to the inhibition of their hepatic uptake

Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion

Samland CJ, Musser RE, Peters JK, Sawyer JT, Owen KQ, Davis DL

This therapeutic rationale has driven investigations into various pharmacological agents and their delivery methods

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