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Recent groundbreaking findings have identified GTPSCS as lactyl-CoA synthetase in the nucleus of glioma cells, promoting glioma progression through P300-mediated histone lactylation [23]

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the Shanghai Municipal Science and Technology Major Project (2019SHZDZX02 to HEX)

This step might involve acid-base catalysis by the active-site cysteinyl thiolate (which could explain an effect of the second cysteinyl residue), and/or the conserved lysine residue, yielding GS in analogy to glutathione transferases (Fig