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In contrast, the combination of CB-839/telaglenastat with multiple tyrosine kinase receptor inhibitor cabozantinib did not improve the efficacy of cabozantinib in patients with advanced RCC in the CANTATA phase II randomized clinical trial (NCT03428217), although it was well tolerated [163]

5.2.4 Polyphenol oxidases (PPOs) PPOs are omnipresent Cu-containing enzymes which utilize molecular Oxygen for catalytic hydroxylation and dehydrogenation of o- diphenolic compounds like catechol and caffeic acid to their respective quinones, which leads to the alkylation of nucleophilic groups and self-polymerization to produce dark-coloured melanin polymers [185]

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Published July 1, 2013.

10.1016/j.phymed.2020.153218 328 SahaS.PanigrahiD