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take 24 weeks off before repeating [5]

In the kindling model, chronic administration of subconvulsive doses of PTZ initiates the recurrence of seizures in a similar manner to the human epilepsy more than the acute models, where the seizure severity increases in a stepwise manner with each PTZ injection inducing severe generalized tonic-clonic seizures (Shimada and Yamagata 2018)

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Conventional oral dosage forms do not resolve the issues with bioavailability and poor pharmacokinetics once administered, which invariably makes these nutraceuticals unsuitable for use as a therapy intervention

Supplementary information Supplementary Notes 1 and 2, Supplementary Tables 17 and Supplementary Figs