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Auristatin-based payloads, such as the conventional monomethyl auristatin E (MMAE), are exceptionally potent microtubule inhibitors with IC 50 values typically ranging from 10 to 100 pM against various cancer cell lines

[DOI] [PubMed] [Google Scholar] 387.Pearce E.N., Lazarus J.H., Moreno-Reyes R., Zimmermann M.B

Fu PP, Xia Q, Hwang HM, Ray PC, Yu H

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283 , F826F838 (2002)

For athletes in hard training, the prospect of preventing or even reversing some of the age-related decline in physical performance is enticing, holding out the promise of longer careers, including more sustained levels of peak performance