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[DOI] [PubMed] [Google Scholar] 59.Alkhateeb A.A., Connor J.R

The mechanism of action for LDN is that it temporarily blocks opioid receptors in the Central Nervous System (CNS)

(2023), who noted its ability to suppress inflammation, OS, and tubular cell apoptosis while promoting autophagy flux through a shift towards the intrarenal ACE2/Ang1-7 axis and away from the intrarenal ACE/Ang II axis

Moreover, cancer cells upregulate antioxidant pathways to maintain redox balance amidst oxidative stress and mitochondrial dysfunction, crucial for their survival (139141)