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6.2 Modulating glial amplification loops 6.2.1 Therapeutic strategies targeting microglial ferroptosis 6.2.1.1 Microglial polarization modulation and ferroptosis inhibition Microglia play a crucial role in the pathogenesis of PD, particularly through promoting ferroptosis, a process exacerbated by pro-inflammatory M1 polarization

It is sourced both from the diet and synthesized within the body from the essential AA methionine through the transmethylation and transsulfuration pathways (Cunningham et al