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When cells grew to 90% confluence, they were starved for 24 h in serum-free medium

Induction of apoptosis by S -nitrosoglutathione and Cu 2+ or Ni 2+ ion through modulation of bax, bad, and bcl-2 proteins in human colon adenocarcinoma cells

G.Aston-MourneyK.ConnorT.McGeeS

10.1093/nar/gky589 73 LeopoldJ

Intriguingly, Syn WT showed no detectable binding affinity towards the Syn WT -141C construct, indicating that monomeric Syn is functionally inert in solution (Fig

These findings are supported by survival analyses demonstrating that combinatorial approaches using TMZ with ferroptosis inducers (erastin, sorafenib) extend median survival by 4060% compared to TMZ monotherapy in orthotopic models [162]