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These results demonstrate that inhibiting ferroptosis, rather than activating the AMPK pathway, is the primary mechanism of action of metformin against IIRI

10.1016/j.jacc.2022.02.008 150

However, NS3 from replicon cells, ectopically expressed NS3 in the context of NS3-5B and NS3/4A, all showed the same difference

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Kankwatira AM, Mwafulirwa GA, Gordon MA

Non-cell-autonomous cancer progression from chromosomal instability