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Grupos posteriores confirmaron la presencia de FAD y del grupo tiol, y se sugiri un mecanismo por primera vez en 1965

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GoldhaberSHeitJSharmaGNagelJSKimDParkerJAet alRandomised controlled trial of recombinant tissue plasminogen activator versus urokinase in the treatment of acute pulmonary embolism

GI symptoms, including excessive salivation, dysphagia, constipation, esophageal motility disorders, and gastric abnormalities, occur many years before the appearance of motor symptoms and may be associated with an increased risk of developing PD [112]