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This means we have interesting data but not definitive conclusions

Wang Q, Gao J, Di W, Wu X

Peptidoglycan recognition by the immune system is probably mediated by the nucleotide-binding oligomerization domain (NOD) with the consequent alteration of pro-inflammatory pathways such as NF-kB and MAP kinase [68]

While challenges in translating findings from animal models to human patients due to differences in important factors such as IVD size, cell turnover, and biomechanical load need to be acknowledged and carefully considered, the usefulness of these experimental models cannot be ignored

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(71), and higher MMP-9 has been reported in younger youth diagnosed with bipolar disorder compared to older adults (72)