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Subjects in the sq MTX group not achieving an ACR20 response at 16 weeks had their sq MTX dosage increased to 20 mg per week

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More serious B12 deficiencies have the potential to impair heart and neurological function, leading to a wide range of serious symptoms, including but not limited to tinnitus, severe joint pain, memory problems, depression, anxiety, poor muscle function, ataxia and changes in reflexes