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Shibao C, Arzubiaga C, Roberts LJ, Raj S, Black B, Harris P, Biaggioni I

In the future, by integrating AI-driven closed-loop neuromodulation, multi-target drug intervention, and neuro-microbiome precision strategies, the spatiotemporal signal network of 7nAChR and the multi-transmitter synergistic mechanism can be analyzed to achieve individualized neuro-immune treatment for diseases such as sepsis

Herein, we did not identify studies that correlated effort-related motivational aspects, such as those assessed by the Effort-Based Decision-Making and Learned Helplessness tests, in animal models of anxiety or depression subjected to exposure to caffeine and related xanthines, while also evaluating inflammatory parameters

So it is better to simulate human NAFLD characteristics with conditions for obesity, insulin resistance, and systemic inflammation (Santhekadur et al., 2018)

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