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The high expression of D3 in regenerating liver tissue and certain tumors and the crucial role of D2 and D3 in muscle regeneration (3, 106, 123, 159, 197, 214) suggest that coordinated regulation of thyroid hormone action is essential in the control of the tight balance between proliferation and differentiation in the regeneration processes, and that high expression of D3 may also be an advantage in proliferating tumor cells (98, 101, 147)