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These hypoxic episodes are followed by rapid reoxygenation, which triggers a surge in the production of ROS through mechanisms such as mitochondrial dysfunction and activation of NADPH oxidase pathways (Stanek et al., 2021)

20 While Class I FINs have shown some promise as inducers of ferroptosis in cancer cells in vivo , the development of analogs with greater potency in vivo remains a high priority.14,17,21 Inhibiting GPX4 has recently been pinpointed as a means to selectively kill drug-resistance cancer cell sub-populations

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Increase BPC-157 to target dose Weeks 4 to 12: Maintain all three peptides at target doses Week 12+: Reassess