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Despite its use over the past seven decades, multiple placebo-controlled designs have shown no significant improvement in pain, degree of curvature, plaque size, or ability to have intercourse

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We rated the certainty for each comparison and outcome as high, moderate, low, or very low, taking into consideration the risk of bias [26], inconsistency [27], imprecision [28, 29], indirectness [30], and publication bias [31]